The TIBCO Spotfire installed client crashes upon start up, and a pop up will appear stating:

TIBCO Spotfire has stopped working
A problem caused the program to stop working correctly. Windows will close this program and notify you if a solution is available.

In the Event Viewer, you will see an event like:

Log Name:      Application
Source:        .NET Runtime
Date:          1/1/2019 11:36:24 AM
Event ID:      1026
Task Category: None
Level:         Error
Keywords:      Classic
User:          N/A
Computer:      myComputer
Description:
Application: Spotfire.Dxp.exe
Framework Version: v4.0.30319
Description: The process was terminated due to an unhandled exception.
Exception Info: System.Xml.XmlException
   at System.Xml.XmlTextReaderImpl.Throw(System.Exception)
   at System.Xml.XmlTextReaderImpl.ParseDocumentContent()
   at System.Xml.XmlLoader.Load(System.Xml.XmlDocument, System.Xml.XmlReader, Boolean)
   at System.Xml.XmlDocument.Load(System.Xml.XmlReader)
   at Spotfire.Dxp.Internal.Xml.SafeXmlHelper.LoadXmlDocument(System.IO.TextReader)
   at Spotfire.Dxp.Framework.ModuleHandling.ModuleReferenceCollection.Read(System.String)
   at Spotfire.Dxp.Framework.ModuleHandling.ModuleReferenceCollection.ReadFromFile(System.String)
   at Starter.Program.Run(Spotfire.Dxp.Starter.StarterSplashWrapper, System.Collections.Generic.Dictionary`2<System.String,System.Object>, Boolean)
   at Starter.Program.ExecuteRunLoopWithBootstrapFlag(System.String[], Boolean)
   at Starter.Program.Main(System.String[])

This is caused by one of the internal configuration files being corrupted, or empty (0 KB). For example, if the "ProbedModulesCached.xml" file in folder C:\Users\USERNAME\AppData\Local\TIBCO\Spotfire\x.xx\Settings is found to be empty and 0 KB, then this crash will occur. 

To resolve, delete the 0 KB sized "ProbedModulesCached.xml" file, and launch the client again. The file will get automatically created again by the client and the client should successfully launch.

TIBCO Spotfire installed client crashes on startup when the size of file the "ProbedModulesCached.xml" is 0 KB or corrupt