If you are installing TIBCO Scribe® Insight and are getting a message that a reboot is required (even after you have just rebooted), then there are a couple of possible causes.  There may be a Windows Update that may not have installed properly and preventing a reboot from being effective in completing the upgrade.  Check the Windows Update > View update history for any updates that may have failed and require attention before a reboot will successfully install the update.  Second, you may have some orphaned registry keys left over from a previous install or installs.

The existence of the Registry files below may cause this error.  Make a backup copy of the Registry and then delete the key(s) listed below.  It is common to find just one of the keys listed below.  After deleting the keys below, right-click - Run as Administrator on Setup.exe to open the Install Wizard.  

HKEY_LOCAL_MACHINE\SYSTEM\CurrentControlSet\Control\Session Manager\PendingFileRenameOperations

The file above is the most common, however those below can also trigger this behavior:

HKEY_LOCAL_MACHINE\SOFTWARE\Microsoft\Windows\CurrentVersion\RunOnce
HKEY_LOCAL_MACHINE\SOFTWARE\Microsoft\Windows\CurrentVersion\RunOnceEx
HKEY_LOCAL_MACHINE\SOFTWARE\Microsoft\Windows\CurrentVersion\Installer\InProgress
 
If working on a 64-bit machine, you may find the settings in the following registry keys instead of those listed above:
 
HKEY_LOCAL_MACHINE\SOFTWARE\WOW6432Node\Microsoft\Windows\CurrentVersion\RunOnce
HKEY_LOCAL_MACHINE\SOFTWARE\WOW6432Node\Microsoft\Windows\CurrentVersion\RunOnceEx
HKEY_LOCAL_MACHINE\SOFTWARE\WOW6432Node\Microsoft\Windows\CurrentVersion\Installer\InProgress