After installation of the hotfix for the Apache Cassandra plugin the below error message can be observed in appnode log,that can also be observed on bwadmin console:
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com.tibco.bw.thor.runtime.model.Constituent - TIBCO-BW-FRWK-600000: com.tibco.bx.core.faults.BxException: BX-600037: Init module failed for module [com.mafretail.erceipts.provider.cassandra.module] version [1.0.0.20190320114256] application [com.mafretail.erceipts.provider.cassandra.module.application 1.0].
   <CausedBy> com.tibco.bx.core.faults.BxException: BX-600037: Init module failed for module [com.mafretail.erceipts.provider.cassandra.module] version [1.0.0.20190320114256] application [com.mafretail.erceipts.provider.cassandra.module.application 1.0].
   <CausedBy> com.tibco.bw.core.runtime.ActivityCreationException: TIBCO-BW-CORE-500612: Failed to create the activity [Update] in process [com.mafretail.erceipts.provider.cassandra.module.logic.CallCassandra], module [com.mafretail.erceipts.provider.cassandra.module] due to exception [com.tibco.neo.exception.BaseException].
   <CausedBy> com.tibco.neo.exception.BaseException: WARNING: exception with message ***TIBCO-BW-FRWK-600001: No ComponentFactory found for activity type bw.cassandra.Update. The palette with this activity may not be installed.*** has not been localized
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This issue occurred when bwagent is running then that time application config data locked by bwagent.When bwagent running if the user has installed a hotfix or upgrade plugin then config data is getting updated correctly.  

After installation of the hotfix for the Apache Cassandra plugin, the application gets stopped.

Product: TIBCO ActiveMatrix BusinessWorks Plug-in for Apache Cassandra Version:6.3.x OS: All Supported Operating Systems

To resolve this issue make sure that bwagent, bwadmin or appnode process are in the stopped during installation/upgrading the plugin then follow the below steps:

1) Un-deploy all applications from the appspace.
2) Stop bwagent, bwadmin and appnode process.
3) Delete the 'configstorage' and 'org.eclipse.osgi' folder in the domains/<domain_name>/appnodes/<space_name>/<node_name>/config folder. 
4) Start bwagent, appnode and bwadmin(for command line deployment)
5) Again deploy the applications