TIBCO Spotfire can be installed on any Virtualized or Cloud environments as long as all the System Requirements are met as per:
and that the virtual machines can communicate without interference.
TIBCO Spotfire installations on cloud hosted virtual machines are fully supported. Please see the "2.5 Virtualized and Cloud Environment Support" section of the TIBCO Support Guide for details:
Note: TIBCO Support is available to help with TIBCO Spotfire installation problems, issues encountered while using the product, configuration errors, and product troubleshooting and diagnosis, but not the administration of the virtual machines or cloud infrastructure.