-----------------
2018 May 21 12:24:41:183 GMT +0200 R3AdapterConfiguration Warn [Adapter] AER3-970276 Server Exception: 
Gateway Host: xxxxxxxxxxx 
Gateway Service: sapgw00 
Program ID: xxxxxxxxxx 
Error Message: Server startup failed at Mon May 21 12:24:41 CEST 2018. 
This is caused by either a) erroneous server settings, b) the backend system has been shutdown, c) network problems. Will try next startup in 1 seconds. 
Could not start server: Connect to SAP gateway failed 
Connection parameters: PROGID=xxxxxx GWHOST=xxxxxxxxx GWSERV=sapgw00 TRACE=x 

ERROR service '?' unknown
TIME Mon May 21 12:24:41 2018 
RELEASE xxx 
COMPONENT NI (network interface) 
VERSION 40 
RC -3 
DETAIL NiErrSet 
COUNTER 2 
-----------------

This exception will occurs if port number and sap gateway service were not mapped on the machine where the TIBCO ActiveMatrix® Adapter for SAP application is running. In order to resolve this issue, follow the below given steps:

1. Open services file, this file present in the below location -
---------------------------------------
Windows OS -   C:\Windows\System32\drivers\etc
Unix OS        -    /etc/services
---------------------------------------

2. As per the above mentioned sample exception, gateway service is sapgw00. Add below one line to the services file to resolve this issue.
---------------------------------------
sapgw00  3300/tcp
---------------------------------------

OR

Add below all these lines to the end of the services file. This will helps, If application using some another gateway services.

sapdp00  3200/tcp
sapdp01  3201/tcp
sapdp02  3202/tcp
sapdp03  3203/tcp
sapdp04  3204/tcp
sapdp05  3205/tcp
sapdp06  3206/tcp
sapdp07  3207/tcp
sapdp08  3208/tcp
sapdp09  3209/tcp
sapdp10  3210/tcp
sapdp11  3211/tcp
sapdp12  3212/tcp
sapdp13  3213/tcp
sapdp14  3214/tcp
sapdp15  3215/tcp
sapdp16  3216/tcp
sapdp17  3217/tcp
sapdp18  3218/tcp
sapdp19  3219/tcp
sapdp20  3220/tcp
sapdp21  3221/tcp
sapdp22  3222/tcp
sapdp23  3223/tcp
sapdp24  3224/tcp
sapdp25  3225/tcp
sapdp26  3226/tcp
sapdp27  3227/tcp
sapdp28  3228/tcp
sapdp29  3229/tcp
sapdp30  3230/tcp
sapdp31  3231/tcp
sapdp32  3232/tcp
sapdp33  3233/tcp
sapdp34  3234/tcp
sapdp35  3235/tcp
sapdp36  3236/tcp
sapdp37  3237/tcp
sapdp38  3238/tcp
sapdp39  3239/tcp
sapdp40  3240/tcp
sapdp41  3241/tcp
sapdp42  3242/tcp
sapdp43  3243/tcp
sapdp44  3244/tcp
sapdp45  3245/tcp
sapdp46  3246/tcp
sapdp47  3247/tcp
sapdp48  3248/tcp
sapdp49  3249/tcp
sapdp50  3250/tcp
sapdp51  3251/tcp
sapdp52  3252/tcp
sapdp53  3253/tcp
sapdp54  3254/tcp
sapdp55  3255/tcp
sapdp56  3256/tcp
sapdp57  3257/tcp
sapdp58  3258/tcp
sapdp59  3259/tcp
sapdp60  3260/tcp
sapdp61  3261/tcp
sapdp62  3262/tcp
sapdp63  3263/tcp
sapdp64  3264/tcp
sapdp65  3265/tcp
sapdp66  3266/tcp
sapdp67  3267/tcp
sapdp68  3268/tcp
sapdp69  3269/tcp
sapdp70  3270/tcp
sapdp71  3271/tcp
sapdp72  3272/tcp
sapdp73  3273/tcp
sapdp74  3274/tcp
sapdp75  3275/tcp
sapdp76  3276/tcp
sapdp77  3277/tcp
sapdp78  3278/tcp
sapdp79  3279/tcp
sapdp80  3280/tcp
sapdp81  3281/tcp
sapdp82  3282/tcp
sapdp83  3283/tcp
sapdp84  3284/tcp
sapdp85  3285/tcp
sapdp86  3286/tcp
sapdp87  3287/tcp
sapdp88  3288/tcp
sapdp89  3289/tcp
sapdp90  3290/tcp
sapdp91  3291/tcp
sapdp92  3292/tcp
sapdp93  3293/tcp
sapdp94  3294/tcp
sapdp95  3295/tcp
sapdp96  3296/tcp
sapdp97  3297/tcp
sapdp98  3298/tcp
sapdp99  3299/tcp
sapgw00  3300/tcp
sapgw01  3301/tcp
sapgw02  3302/tcp
sapgw03  3303/tcp
sapgw04  3304/tcp
sapgw05  3305/tcp
sapgw06  3306/tcp
sapgw07  3307/tcp
sapgw08  3308/tcp
sapgw09  3309/tcp
sapgw10  3310/tcp
sapgw11  3311/tcp
sapgw12  3312/tcp
sapgw13  3313/tcp
sapgw14  3314/tcp
sapgw15  3315/tcp
sapgw16  3316/tcp
sapgw17  3317/tcp
sapgw18  3318/tcp
sapgw19  3319/tcp
sapgw20  3320/tcp
sapgw21  3321/tcp
sapgw22  3322/tcp
sapgw23  3323/tcp
sapgw24  3324/tcp
sapgw25  3325/tcp
sapgw26  3326/tcp
sapgw27  3327/tcp
sapgw28  3328/tcp
sapgw29  3329/tcp
sapgw30  3330/tcp
sapgw31  3331/tcp
sapgw32  3332/tcp
sapgw33  3333/tcp
sapgw34  3334/tcp
sapgw35  3335/tcp
sapgw36  3336/tcp
sapgw37  3337/tcp
sapgw38  3338/tcp
sapgw39  3339/tcp
sapgw40  3340/tcp
sapgw41  3341/tcp
sapgw42  3342/tcp
sapgw43  3343/tcp
sapgw44  3344/tcp
sapgw45  3345/tcp
sapgw46  3346/tcp
sapgw47  3347/tcp
sapgw48  3348/tcp
sapgw49  3349/tcp
sapgw50  3350/tcp
sapgw51  3351/tcp
sapgw52  3352/tcp
sapgw53  3353/tcp
sapgw54  3354/tcp
sapgw55  3355/tcp
sapgw56  3356/tcp
sapgw57  3357/tcp
sapgw58  3358/tcp
sapgw59  3359/tcp
sapgw60  3360/tcp
sapgw61  3361/tcp
sapgw62  3362/tcp
sapgw63  3363/tcp
sapgw64  3364/tcp
sapgw65  3365/tcp
sapgw66  3366/tcp
sapgw67  3367/tcp
sapgw68  3368/tcp
sapgw69  3369/tcp
sapgw70  3370/tcp
sapgw71  3371/tcp
sapgw72  3372/tcp
sapgw73  3373/tcp
sapgw74  3374/tcp
sapgw75  3375/tcp
sapgw76  3376/tcp
sapgw77  3377/tcp
sapgw78  3378/tcp
sapgw79  3379/tcp
sapgw80  3380/tcp
sapgw81  3381/tcp
sapgw82  3382/tcp
sapgw83  3383/tcp
sapgw84  3384/tcp
sapgw85  3385/tcp
sapgw86  3386/tcp
sapgw87  3387/tcp
sapgw88  3388/tcp
sapgw89  3389/tcp
sapgw90  3390/tcp
sapgw91  3391/tcp
sapgw92  3392/tcp
sapgw93  3393/tcp
sapgw94  3394/tcp
sapgw95  3395/tcp
sapgw96  3396/tcp
sapgw97  3397/tcp
sapgw98  3398/tcp
sapgw99  3399/tcp

3. Save the file and restart your application (rebooting the machine shouldn't be required)

Note: There is a known issue that Windows does not read the last entry of services file, if the entries were appended at the bottom of the file, please make sure there is an extra blank line as the last line of the file.