TIBCO Spotfire Statistics Services (TSSS) server with the default H2 database installed on Linux OS may fail to start with the following error in SplusServer.log:
org.h2.jdbc.JdbcSQLException: Database may be already in use: "Locked by another process"

This error can occur on both standalone as well as clustered TSSS deployments. The SplusServer.log will have the following log entries when the service fails to start:
2019-11-13 10:17:36,940 | ERROR |  | ContextLoader | Context initialization failed
org.springframework.beans.factory.BeanCreationException: Error creating bean with name 'com.insightful.splusserver.SplusStateInitializer#0' defined in class path resource [applicationContext-job-execution.xml]: Invocation of init method failed; nested exception is org.springframework.transaction.CannotCreateTransactionException: Could not open JDBC Connection for transaction; nested exception is org.apache.commons.dbcp.SQLNestedException: Cannot create PoolableConnectionFactory (Database may be already in use: "Locked by another process". Possible solutions: close all other connection(s); use the server mode; SQL statement:
null/161b3f6d8a44ce64ebc5fb175c35d46142bc679b47e [90020-129])
at org.springframework.beans.factory.support.AbstractAutowireCapableBeanFactory.initializeBean(AbstractAutowireCapableBeanFactory.java:1514)
at org.springframework.beans.factory.support.AbstractAutowireCapableBeanFactory.doCreateBean(AbstractAutowireCapableBeanFactory.java:521)
at org.springframework.beans.factory.support.AbstractAutowireCapableBeanFactory.createBean(AbstractAutowireCapableBeanFactory.java:458)
at org.springframework.beans.factory.support.AbstractBeanFactory$1.getObject(AbstractBeanFactory.java:293)
at org.springframework.beans.factory.support.DefaultSingletonBeanRegistry.getSingleton(DefaultSingletonBeanRegistry.java:223)
at org.springframework.beans.factory.support.AbstractBeanFactory.doGetBean(AbstractBeanFactory.java:290)
at org.springframework.beans.factory.support.AbstractBeanFactory.getBean(AbstractBeanFactory.java:191)
at org.springframework.beans.factory.support.DefaultListableBeanFactory.preInstantiateSingletons(DefaultListableBeanFactory.java:636)
at org.springframework.context.support.AbstractApplicationContext.finishBeanFactoryInitialization(AbstractApplicationContext.java:938)
at org.springframework.context.support.AbstractApplicationContext.refresh(AbstractApplicationContext.java:479)
at org.springframework.web.context.ContextLoader.configureAndRefreshWebApplicationContext(ContextLoader.java:410)
at org.springframework.web.context.ContextLoader.initWebApplicationContext(ContextLoader.java:306)
at org.springframework.web.context.ContextLoaderListener.contextInitialized(ContextLoaderListener.java:112)
at org.apache.catalina.core.StandardContext.listenerStart(StandardContext.java:4745)
at org.apache.catalina.core.StandardContext.startInternal(StandardContext.java:5207)
at org.apache.catalina.util.LifecycleBase.start(LifecycleBase.java:150)
at org.apache.catalina.core.ContainerBase.addChildInternal(ContainerBase.java:752)
at org.apache.catalina.core.ContainerBase.addChild(ContainerBase.java:728)
at org.apache.catalina.core.StandardHost.addChild(StandardHost.java:734)
at org.apache.catalina.startup.HostConfig.deployWAR(HostConfig.java:988)
at org.apache.catalina.startup.HostConfig$DeployWar.run(HostConfig.java:1860)
at java.util.concurrent.Executors$RunnableAdapter.call(Executors.java:511)
at java.util.concurrent.FutureTask.run(FutureTask.java:266)
at java.util.concurrent.ThreadPoolExecutor.runWorker(ThreadPoolExecutor.java:1149)
at java.util.concurrent.ThreadPoolExecutor$Worker.run(ThreadPoolExecutor.java:624)
at java.lang.Thread.run(Thread.java:748)
Caused by: org.springframework.transaction.CannotCreateTransactionException: Could not open JDBC Connection for transaction; nested exception is org.apache.commons.dbcp.SQLNestedException: Cannot create PoolableConnectionFactory (Database may be already in use: "Locked by another process". Possible solutions: close all other connection(s); use the server mode; SQL statement:
null/161b3f6d8a44ce64ebc5fb175c35d46142bc679b47e [90020-129])
at org.springframework.jdbc.datasource.DataSourceTransactionManager.doBegin(DataSourceTransactionManager.java:243)
at org.springframework.transaction.support.AbstractPlatformTransactionManager.getTransaction(AbstractPlatformTransactionManager.java:372)
at org.springframework.transaction.interceptor.TransactionAspectSupport.createTransactionIfNecessary(TransactionAspectSupport.java:417)
at org.springframework.transaction.interceptor.TransactionAspectSupport.invokeWithinTransaction(TransactionAspectSupport.java:255)
at org.springframework.transaction.interceptor.TransactionInterceptor.invoke(TransactionInterceptor.java:94)
at org.springframework.aop.framework.ReflectiveMethodInvocation.proceed(ReflectiveMethodInvocation.java:172)
at org.springframework.aop.framework.JdkDynamicAopProxy.invoke(JdkDynamicAopProxy.java:204)
at com.sun.proxy.$Proxy5.processUnfinishedJobs(Unknown Source)
at com.insightful.splusserver.SplusStateInitializer.init(SplusStateInitializer.java:40)
at sun.reflect.NativeMethodAccessorImpl.invoke0(Native Method)
at sun.reflect.NativeMethodAccessorImpl.invoke(NativeMethodAccessorImpl.java:62)
at sun.reflect.DelegatingMethodAccessorImpl.invoke(DelegatingMethodAccessorImpl.java:43)
at java.lang.reflect.Method.invoke(Method.java:498)
at org.springframework.beans.factory.support.AbstractAutowireCapableBeanFactory.invokeCustomInitMethod(AbstractAutowireCapableBeanFactory.java:1640)
at org.springframework.beans.factory.support.AbstractAutowireCapableBeanFactory.invokeInitMethods(AbstractAutowireCapableBeanFactory.java:1581)
at org.springframework.beans.factory.support.AbstractAutowireCapableBeanFactory.initializeBean(AbstractAutowireCapableBeanFactory.java:1511)
... 25 more
Caused by: org.apache.commons.dbcp.SQLNestedException: Cannot create PoolableConnectionFactory (Database may be already in use: "Locked by another process". Possible solutions: close all other connection(s); use the server mode; SQL statement:
null/161b3f6d8a44ce64ebc5fb175c35d46142bc679b47e [90020-129])
at org.apache.commons.dbcp.BasicDataSource.createDataSource(BasicDataSource.java:1225)
at org.apache.commons.dbcp.BasicDataSource.getConnection(BasicDataSource.java:880)
at org.springframework.jdbc.datasource.DataSourceTransactionManager.doBegin(DataSourceTransactionManager.java:202)
... 40 more
Caused by: org.h2.jdbc.JdbcSQLException: Database may be already in use: "Locked by another process". Possible solutions: close all other connection(s); use the server mode; SQL statement:
null/161b3f6d8a44ce64ebc5fb175c35d46142bc679b47e [90020-129]
at org.h2.message.DbException.getJdbcSQLException(DbException.java:317)
at org.h2.message.DbException.get(DbException.java:168)
at org.h2.message.DbException.get(DbException.java:145)
at org.h2.store.FileLock.getExceptionAlreadyInUse(FileLock.java:433)
at org.h2.store.FileLock.lockFile(FileLock.java:329)
at org.h2.store.FileLock.lock(FileLock.java:129)
at org.h2.engine.Database.open(Database.java:513)
at org.h2.engine.Database.openDatabase(Database.java:200)
at org.h2.engine.Database.<init>(Database.java:195)
at org.h2.engine.Engine.openSession(Engine.java:56)
at org.h2.engine.Engine.openSession(Engine.java:140)
at org.h2.engine.Engine.getSession(Engine.java:120)
at org.h2.engine.Session.createSession(Session.java:119)
at org.h2.engine.SessionRemote.connectEmbeddedOrServer(SessionRemote.java:236)
at org.h2.engine.SessionRemote.createSession(SessionRemote.java:214)
at org.h2.jdbc.JdbcConnection.<init>(JdbcConnection.java:111)
at org.h2.jdbc.JdbcConnection.<init>(JdbcConnection.java:95)
at org.h2.Driver.connect(Driver.java:58)
at org.apache.commons.dbcp.DriverConnectionFactory.createConnection(DriverConnectionFactory.java:38)
at org.apache.commons.dbcp.PoolableConnectionFactory.makeObject(PoolableConnectionFactory.java:294)
at org.apache.commons.dbcp.BasicDataSource.validateConnectionFactory(BasicDataSource.java:1247)
at org.apache.commons.dbcp.BasicDataSource.createDataSource(BasicDataSource.java:1221)

1. Stop the TSSS service. For clustered installations, stop all Manager nodes and Worker nodes.
2. Check if there is still ‘db.lock.db’ file inside the H2 folder. 
   • For standalone installations, check inside <TSSS installation>\h2 folder. 
   • For clustered installations, check inside <Cluster Shared path>\h2 folder.
3. If the ‘db.lock.db’ file exists in the above folder location, check if there are any stale Java processes which are still holding a lock on the H2 database. Run the following command to find any such processes and terminate them.

ps -ef | grep spserver   

• https://stackoverflow.com/questions/8158969/h2-database-error-database-may-be-already-in-use-locked-by-another-process