On the WebsphereMQ side:
1). Create two Queue Managers, one named QM1, set as the default Queue Manager and the other named QM2.
2). Create a Sever-connection Channel named CONN in QM1 and QM2 and create a client connection channel. In the client connection channel's property, specify a connection name such as: <QM1 machine ip>(QM1 listener),<QM2 machine ip>(QM2 listener). For example, 192.168.69.79(1414),192.168.69.86(1415). Note that there is no need to specify the Queue Manager name in this step.
On the MQ Adapter side:
3). The MQ Adapter works as an MQ Client node. Leave the Queue Manager name blank under the Run-time Connection tab in Designer.
4). Specify "Parameters for test connection" under the Run-time Connection tab as Sever-connection Channel/TCP/<QM1 machine ip>(QM1 listener),<QM1 machine ip>(QM1 listener). For example, CONN/TCP/192.168.69.79(1414),192.168.69.86(1415).